Status of selected ion flow tube mass spectrometry ; accomplishments and 3 challenges in breath analysis and other areas

18 This “Perspective” reflects our observations of recent accomplishments made using SIFT19 MS. Only brief descriptions are given of SIFT-MS as an analytical method and of the recent 20 extensions to the underpinning analytical ion chemistry required to realise more robust 21 analyses. The challenge of breath analysis is given special attention because, when achieved, 22 it renders analysis of other air media relatively straightforward. Brief overviews are given of 23 recent SIFT-MS breath analyses by leading research groups, noting the desirability of 24 detection and quantification of single volatile biomarkers rather than reliance on statistical 25 analyses, for breath analysis is to be accepted into clinical practice. A “SWOT” analysis of 26 SIFT-MS is made which should increase its utility for trace gas analysis. 27